The Week 6 schedule begins with an NFC West showdown between the San Francisco 49ers and Seattle Seahawks. The 2-3 49ers, who are winless in the division, face the first-place Seahawks, who are 3-2 but have yet to play a game in the NFC West. Both teams are winless (the 49ers 0-3 and the Seahawks 0-2) in conference games. They kick off from Lumen Field at 8:15 p.m. ET on Amazon Prime Video. Who will win the game? What are the best betting picks?
49ers at Seahawks odds
Moneyline:
- 49er -190
- Seahawks +155
Moneyline:
- 49er -190
- Seahawks +155
Spread:
- 49ers -3.5 (-110)
- Seahawks +3.5 (-110)
Total
- Over 48.5 (-110)
- Under 48.5 (-110)
49ers at Seahawks picks and predictions
Moneyline:
- 49ers -190
The 49ers are generally viewed as the better team, it feels highly unlikely they would start 0-3 in the division and they have won the last 5 meetings with Seattle. ATS
- 49ers -3.5 (-110)
Both of the Niners’ wins were by double digits. The Seahawks are 1-3-1 ATS. Total
- Over 48.5
The Niners scored over 30 in both wins. Get more Cardinals and NFL coverage from Cards Wire’s Jess Root and others by listening to the latest on the Rise Up, See Red podcast. Subscribe on Spotify, YouTube or Apple podcasts.